Posted by Quintal on March 30, 2008, at 18:02:26
In reply to Re: Parnate metabolites » Quintal, posted by Larry Hoover on March 30, 2008, at 17:26:36
>The similarity in the structures undoubtedly leads to poor resolution during analysis, leading to false positives for amphetamine on screening tests. However, more specific tests have always failed to find amphetamine as a metabolite of tranylcypromine.
Well there's one here that detected amphetamine, methamphetamine and PEA by gas chromatography in the plasma of another Parnate overdose. It says their identity was confirmed by mass spectrometry.
__________________________________________________1: Psychol Med. 1979 May;9(2):377-82.Links
Tranylcypromine ('Parnate') overdose: measurement of tranylcypromine concentrations and MAO inhibitory activity and identification of amphetamines in plasma.
Youdim MB, Aronson JK, Blau K, Green AR, Grahame-Smith DG.A case of tranylcypromine overdose is reported. Tranylcypromine, amphetamine methamphetamine and phenylethylamine were detected in the plasma by gas chromatography and their identity confirmed by mass spectrometry. The data suggested that the amphetamines were metabolic products of tranylcypromine. Platelet monoamine oxidase activity was more than 95% inhibited during the 72 h after the overdose despite complete clinical recovery by that time. The possible role of amphetamines and phenylethylamine in causing the clinical manifestations of tranylcypromine overdose is discussed.
PMID: 472083 [PubMed - indexed for MEDLINE]
__________________________________________________It seems unlikely that anyone would be taking amphetamine, methamphetamine and phenylethylamine all at the same time with Parnate on board, and this is the second report I've found that has detected methamphetamine in a Parnate overdose. I also found a report of another two Parnate overdoses where no amphetamine metabolites had been detected. It's always possible that the metabolites were there, but the tests failed to detect them for some reason. Maybe some people metabolize Parnate differently? I don't know.
__________________________________________________1: J Anal Toxicol. 1996 Sep;20(5):301-4.Links
One fatal and one nonfatal intoxication with tranylcypromine. Absence of amphetamines as metabolites.
Iwersen S, Schmoldt A.Department of Legal Medicine, University of Hamburg, Germany.
Two very different cases of overdose with tranylcypromine are presented. One clinical case involving the ingestion of 400 mg tranylcypromine with suicidal intention and one fatality with a suspicion of possible tranylcypromine overdose were examined. Both cases showed similar blood concentrations (0.5 and 0.7 mg/L, respectively), but the clinical case exhibited only mild symptoms of intoxication. The fatality showed no other drugs that could provide an explanation for the death of a 40-year-old male except tranylcypromine. Consideration of the drug concentrations in the fatality in relation to the case findings and other reported data indicates the tranylcypromine overdose as the probable cause of death, despite the low blood concentration. In addition, we looked for evidence of amphetamine as a putative metabolite in both cases. No amphetamines were detected in the overdose cases reported here.
PMID: 8872238 [PubMed - indexed for MEDLINE]
__________________________________________________>As I stated earlier, the structural similarity of tranylcypromine to amphetamine was intentional (according to Goodman and Gillman's 'The Pharmacological Basis of Therapeutics', which is the 'bible' for phsychiatrists and pharmacists, both), in order to confer stimulant activity to the MAOI.
Are you saying tranylcypromine may have stimulant properties in itself?
Q
poster:Quintal
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820740.html