Posted by Larry Hoover on March 30, 2008, at 16:29:14
In reply to Re: Parnate metabolites, posted by Quintal on March 30, 2008, at 16:14:29
> I'm not sure what to make of the tone of your own post Larry...
I'm scared for posters' safety.
One cannot calculate a safe dose based on LD50. One cannot predict one's own toxic threshold. One can, however, assume that taking doses that are associated with prior mortalities might not be a safe thing to do. Whether or not coingestion of bioactive amines was a contributing factor does not, IMHO, make the situation any more predictable, even if we knew for sure.....The risk is attributable to the irreversible MAOI. And, the risk is indeed dose-dependent. I would argue that if one finds themselves drawn to doses of tranylcypromine that fall within a therapeutic index of two or less, then one is using the wrong drug.
Lar
poster:Larry Hoover
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820721.html