Posted by Quintal on March 26, 2008, at 15:04:36
In reply to Parnate metabolites, posted by rgb on March 26, 2008, at 10:42:30
I think they were supposed to be mostly methamphetamine and PEA. People have been talking about this for years, but no real answers as yet. I once read a PubMed report of an autopsy where methamphetamine had been found in the body of a Parnate overdose, so it must be some truth in it. I noticed a similar effect re: dose escalation. At one point I was taking 120mg/day and it felt like getting a 'fix' from a stimulant like coke or meth. I've had a theory for a while that MAO inhibition 'augments' or amplifies the stimulant effect of the small amounts of amphetamine metabolites, so despite being produced in relatively small amounts, the metabloites actually have a substantial effect in practice. Of course I don't know if this is actually true.
Q
poster:Quintal
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820001.html