Posted by Quintal on March 30, 2008, at 16:58:03
In reply to Re: Parnate metabolites » Quintal, posted by Larry Hoover on March 30, 2008, at 16:37:56
> I'm scared for posters' safety.
So that's your primary motive?
> One cannot calculate a safe dose based on LD50. One cannot predict one's own toxic threshold. One can, however, assume that taking doses that are associated with prior mortalities might not be a safe thing to do. Whether or not coingestion of bioactive amines was a contributing factor does not, IMHO, make the situation any more predictable, even if we knew for sure.....The risk is attributable to the irreversible MAOI. And, the risk is indeed dose-dependent. I would argue that if one finds themselves drawn to doses of tranylcypromine that fall within a therapeutic index of two or less, then one is using the wrong drug.
>
> LarWith all due respect, I think it's really for the patient and doctor to decide together whether high-dose Parnate is safe and appropriate in their individual case. Usually by the time people have arrived at MAOIs it's a last-ditch attempt after safer drugs have failed anyway.
>With respect to methamphetamine as a potential metabolite of tranylcypromine......
I have no emotional investment in the methamphetamine metabolite theory whatsoever. If your chemistry is as good as it sounds then I'd say you're probably right. However, there have been a number of reports suggesting methamphetamine and other amphetamine-like metabolites over the years, and I think at least one Parnate user tested positive for amphetamines after being forced to undergo a random drug test at work. I'm not a professional scientist so I'm not going to attempt to dissect all of the possibilities therein.
Q
poster:Quintal
thread:819514
URL: http://www.dr-bob.org/babble/neuro/20080204/msgs/820729.html