Posted by Bob on May 18, 2010, at 22:10:19 [reposted on May 20, 2010, at 18:36:23 | original URL]
In reply to Re: Gone with trimipramine, posted by linkadge on May 18, 2010, at 20:30:50
> The TCA's antidepressant effect is (at least partly) due to interaction with opioid receptors. The TCA's display delta agonist like effects, as well as interaction with kappa receptors.
>
> Linkadge
Would any of those actions at opioid, kappa, or delta receptors have anything to do with their putative pain relieving attributes? From most of the reading I've done (and from what my doctor says) the anti-pain properties come from the presence of dual action on serotonin and norepinephrine only. I'm taking nortriptyline now, but it doesn't seem to reduce pain much.
poster:Bob
thread:948075
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948086.html