Posted by CrAzYmEd on May 29, 2010, at 8:44:34
In reply to Prozac, 5HT2C And The Trojan Horse In Lisuride, posted by Brainbeard on May 29, 2010, at 7:37:55
"Anyhow, 5HT2A-agonism inhibits the benefits of both 5HT1A- and 5HT2C-agonism. "
DO you have a source that 5HT2A agonism inhibits the beneficial effect of 5HT1A agonism? While they have opposing effects on dopamine in the frontal cortex this doesnt mean they will counteract eachother benefits completely.
Unless you can show me the source as i'm interested.
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"If you look at this interesting study on lisuride that I found on Erowid: http://www.erowid.org/references/refs_view.php?A=ShowDoc1&ID=3705; you see that lisuride induced stereotypical behaviour in rats as well as intensive mounting, i.e. male sexual behaviour. Stereotypical behaviour indicates the potential to exacerbate or induce obsessive compulsive behaviour. And increased libido is not always fun, althoug the accompanying photo of one female rat mounting the other is rather funny."
--------------Same with all dopamine agonists in the rats probably, however the human studies regarding pramipexole conclude its well tolerated, while the rats love to have some wild sex on lisuride and walk around on it like a maniac, doesnt mean it will induce streotype behaver in the humans. Like i said a friend with OCD found pramipexole moderately effective for it.
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Stimulation of 5-HT1A or 5-HT2A receptors in the ventrolateral periaqueductal gray causes anxiolytic-, but not panicolytic-like effect in rats.
de Paula Soares V, Zangrossi H Jr.Department of Pharmacology, School of Medicine, University of São Paulo, Av. Bandeirantes 3900, CEP: 14049-900 Ribeirão Preto, Brazil.
Abstract
Evidences from studies using electrical or chemical stimulation of the midbrain periaqueductal gray (PAG) suggest that whereas the dorsal PAG is critical for the regulation of panic-related defensive behaviors, the ventrolateral PAG (vlPAG) modulates generalized anxiety-related responses. In the present study we evaluated whether the activation of 5-HT1A and 5-HT2A/2C receptors in the ventrolateral column of the periaqueductal gray (vlPAG) causes differential effects on an anxiety- and a panic-related defensive behavior, respectively, inhibitory avoidance and escape, in male Wistar rats submitted to the elevated T-maze. Our results showed that intra-vlPAG injection of the endogenous agonist serotonin, the 5-HT1A/7 agonist 8-OH-DPAT or 5-HT2A/2C agonist DOI impaired the acquisition of inhibitory avoidance, without interfering with escape performance. The same selective anxiolytic effect was also observed after local administration of the benzodiazepine receptor agonist midazolam. Moreover, as shown by the results of antagonism studies, 5-HT2A receptors are recruited for the anxiolysis caused by serotonin and DOI, while 5-HT1A receptors account for the effect of 8-OH-DPAT. In conclusion, our data show that the activation of 5-HT1A and 5-HT2A receptors in the vlPAG affects defensive responses related to generalized anxiety, but not panic disorder.So 5HT2A agonism is anxiolytic in the periaqueductal gray area, our bad boy causes some good effects in some brain area's. But yeah in other area's it can cause bad effects like the PAG. Either way i'm still far from convinced that 5HT2A is a bad boy, so id definatly would like to see some studies that it inhibits the positive effects of 5HT1A.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/949373.html