Posted by CrAzYmEd on May 28, 2010, at 9:47:04
In reply to Re: Too much dopamine causes anhedonia? » CrAzYmEd, posted by Conundrum on May 28, 2010, at 9:23:31
I dont buy the high dopamine OCD theory, this theory only comes from the low D2 bindin in humans and the fact that antipsychotics work for it.
However, there is loads of evidence for glutamate hyperactivity in OCD, glutamate downregulates D2, wich could be the cause of low D2 binding.
Also a good friend of me had moderate succes with pramipexole for OCD (and this isnt due to reduced dopamine, as he's autoreceptors are fully downregulated by now).
While i havent tried a dopamine agonist, i know that drugs that increase dopamine and NMDA antagonists are highly effective for my OCD.
Memantine, is a D2 agonist besides its nmda antagonism and has been found effective for OCD, prozac wich increases dopamine has been found effective for OCD too.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/949243.html