Posted by CrAzYmEd on May 28, 2010, at 6:18:27
In reply to Too much dopamine causes anhedonia? » linkadge, posted by Conundrum on May 27, 2010, at 21:18:00
Prozac wont cause a dopamine rebound as it raises dopamine itself: (It can really be anything, its impossible to point a effect of the withdrawal to any receptor)
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http://www.ncbi.nlm.nih.gov/pubmed/15741747
"Twelve patients affected by major depression received a single oral dose of fluoxetine in the morning, 5 mg in the first 5 days, 10 mg from the 6th to the 10th day and 20 mg from the 11th to the 40th day. Twelve healthy subjects received a placebo under identical testing procedures. Blood samples were collected at baseline and 7, 10 and 24 h after drug administration on the 1st day of fluoxetine administration at a dose of 5 mg, and on the 1st and the 30th day of fluoxetine administration at a dose of 20 mg (days 11 and 40 of treatment, respectively). We found that plasma norepinephrine, epinephrine and dopamine levels significantly increased after acute and chronic treatment (p < 0.001), reaching the highest concentrations on the last day. No significant changes of these parameters were observed in control patients."
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I highly suggest against antipyschotics for the treatment of anxiety or depression, they should only be used to treat psychotic disorders. The risk of tardive dyskinesia and metabolic problems are not wort it.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/949225.html