Posted by CrAzYmEd on May 29, 2010, at 8:16:34
In reply to Prozac, 5HT2C And The Trojan Horse In Lisuride, posted by Brainbeard on May 29, 2010, at 7:37:55
"You seem to jump to overstatements like 'its 5HT2C antagonism may counteract any anti dopaminergic activity, so in the end its not anti dopaminergic anymore.' That's about as unfounded a prediction as saying that lisuride's 5HT1A-agonism will completely counter its anxiogenic properties. Lisuride probably fosters OCD."
But its not a overstatement as according to this study it DOES increase dopamine, i never made that conclusion just because prozac is a 5HT2C antagonist, i only made that conclusion on the END result.
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http://www.ncbi.nlm.nih.gov/pubmed/15741747
"Twelve patients affected by major depression received a single oral dose of fluoxetine in the morning, 5 mg in the first 5 days, 10 mg from the 6th to the 10th day and 20 mg from the 11th to the 40th day. Twelve healthy subjects received a placebo under identical testing procedures. Blood samples were collected at baseline and 7, 10 and 24 h after drug administration on the 1st day of fluoxetine administration at a dose of 5 mg, and on the 1st and the 30th day of fluoxetine administration at a dose of 20 mg (days 11 and 40 of treatment, respectively). We found that plasma norepinephrine, epinephrine and dopamine levels significantly increased after acute and chronic treatment (p < 0.001), reaching the highest concentrations on the last day. No significant changes of these parameters were observed in control patients."
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Plasma increased of dopamine are increased, after acute and chronic dosing, so unless the dopamine increase comes from something else then 5HT2C antagonism, the serotonine does NOT counteract the 5HT2C antagonism.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/949372.html