Posted by CrAzYmEd on May 23, 2010, at 17:30:37 [reposted on May 24, 2010, at 22:42:06 | original URL]
In reply to Lisuride And The Real Life, posted by Brainbeard on May 23, 2010, at 17:17:50
I know that dopamine agonists and amp are a differend animal, just gave an example.
"Low dose sulpiride blocks dopamine autoreceptors, which regulate and inhibit dopamine release. Risperdal probably also blocks dopamine autoreceptors. Amisulpride does it for sure. Blocking DA autoreceptors increases dopaminergic transmission. Flupentixol also does it, although it hasn't conclusively been proven. Still, both sulpiride and amisulpride are antidopaminergics potent enough to cause hyperprolactinemia even in low doses (same goes for Risperdal)."
--- Agreed.
"You seem to be a little biased about lisuride. You've made your conclusions on what's ' the way to go', based on.. what? Preliminary evidence? Results in the brains of mice? I do this all the time, but it's in the real life that a drug has to prove what it's worth. Please eat this stuff and enlighten us."
I'l give you an example of why i'm excited about this med:
Lets take a look at tandospirone (a potent 5HT1A agonist)"Tandospirone is typically used at a dose of 30 mg/daily[6] taken in divided doses of 10 mg three times per day due to its short half-life. Though originally considered a relatively weak anxiolytic agent,[6] a clinical study found that doubling the dose to 60 mg/daily resulted in a "remarkable anxiolytic effect with an early onset of action, and without significant adverse effects", as well as "excellent anxiolytic efficacy that is comparable to that of the benzodiazepines".[6] [7]"
Lisuride has this property too its dopamine agonism (with alpha 2 antagonism) kinda like tandospirone and trivastal in one so to speak, and besides that we have 5HT7 antagonism wich also is usefull in depression. (5HT7 antagonism potentias antidepressants in mice, and blocking the 5HT7 antaogonism abolishes the antidepressant effect of amisulpiride)
Also note the magic word "potential" i'm not saying lisuride is the magic bullit, just that it has alot of potential.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948719.html