Posted by CrAzYmEd on May 23, 2010, at 18:19:43 [reposted on May 24, 2010, at 22:42:08 | original URL]
In reply to Lisuride Experiences: Mixed Bag, Not The New Cool, posted by Brainbeard on May 23, 2010, at 18:13:42
brainbeard: Those studies where they described a moderate effect, was lisuride used for several weeks or acutely? Negative effects can be expected the first weeks due to a decrease in dopaminergic transmission.
(Yeah i know dopamine agonists decrease dopamine at first, but this completely recovers after a while, leaving you with the originial dopamine transmission the dopamine agonism."After 14 days of PPX treatment, the firing rate of DA had recovered as well as that of NE, whereas the firing rate of 5-HT neurons was increased by 38%. It was also observed that sustained PPX administration produced desensitization of D(2)/D(3) and 5-HT(1A) cell body autoreceptors, as well as a decrease in sensitivity of alpha(2)-adrenergic cell body autoreceptors. These adaptive changes are implicated in long-term firing rate adaptations of DA, NE and 5-HT neurons after prolonged PPX administration. In conclusion, the therapeutic action of PPX in depression might be attributed to increased DA and 5-HT neurotransmission."
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948726.html