Posted by linkadge on May 23, 2010, at 20:32:12 [reposted on May 24, 2010, at 22:42:10 | original URL]
In reply to Lisuride Experiences: Mixed Bag, Not The New Cool, posted by Brainbeard on May 23, 2010, at 18:13:42
I don't buy the notion that dopamine agonists decrease dopamine function (overall). If this were true, why are they effective (long term) for parkinsons disase?
Some agonists, like mirapex, have preferential effects on the presynaptic dopamine receptor. Over time, the drug might well downregulate the dopamine autoreceptor and thus enhance neurotransmission.
Linkadge
poster:linkadge
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948728.html