Posted by CrAzYmEd on May 23, 2010, at 16:06:54 [reposted on May 24, 2010, at 22:42:05 | original URL]
In reply to Interesting - Could Be Key Ingredient Of AD Combo, posted by Brainbeard on May 23, 2010, at 15:43:30
"A potent 5HT1A-agonist could be a key ingredient in an antidepressant cocktail, as Dr. Stahl has marked out. An (S)SRI, a 5HT2A-antagonist and a 5HT1A-agonist, plus perhaps a D2-antagonist, make for a theoretically ideal antidepressant combo, according to Stahl."
I think that 5HT2A AGONISM is better then antagonism, while 5HT2A agonism has also negative effects, 5HT1A agonism seems to completely nullify it (lisuride is a antidepressant/anxiolytic despite its very potent 5HT2A agonism). I beleive that with 5HT1A agonism, 5HT2A AGONISM is the way to go as 5HT2A agonism would increase dopamine in the mesolimbic area's.
5HT2A is also of crucial importance of regulating dopamine release by amp/opiates
"5-HT2A and alpha1b-adrenergic receptors entirely mediate dopamine release, locomotor response and behavioural sensitization to opiates and psychostimulants"Also D2 and D4 agonism are important, D2 is implicated in efford related decission making, so lisuride can be motivating.
Dopamine is also implicated in social anxiety, so D2 agonism would be of benefit it, and not D2 antagonism (wich i think is a bad idea overall, agonism is the way to go).But yeah i agree that this one would do very well in combo's, and imo also on its own.
poster:CrAzYmEd
thread:948688
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948713.html