Posted by Brainbeard on May 24, 2010, at 13:28:27
In reply to Re: Nortriptyline, Desipramine, 5 HT2C?, posted by desolationrower on May 7, 2010, at 19:30:58
Gillman lists a much weaker affinity of nortriptyline for 5HT2A: only 44. He lists a Ki value of 29 for its mother drug, amitriptyline. 35 for clomipramine.
Surely, desipramine is a much more potent NRI than nortriptyline. Gillman lists 0.83 versus 10, respectively.
Gillman unfortunately doesn't mention affinities for 5HT2C receptors.
The problem with binding affinity studies is that Ki values usually vary so wildly that they don't really tell you anything.
Current meds: 10mg melitracene + 0.5mg flupentixol; sertraline 100mg; amitriptyline 25mg; gabapentin (Neurontin) 300mg; melatonin 0.3mg. PRN: diazepam (Valium) 2.5-5mg.
poster:Brainbeard
thread:943541
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/948599.html