Posted by conundrum on April 24, 2010, at 23:59:47
In reply to Re: Nortriptyline, Desipramine, 5 HT2C?, posted by desolationrower on April 23, 2010, at 18:47:38
Thanks for the link! I did some search and found that nortriptyline had a potency of 8.5 at the 5 HT2C receptor which is pretty high and desipramine had a lower potency of 244 at this same receptor.
Nortriptyline's potency at the 5 HT2A receptor was 5. The range for desipramine at 5 HT2A was around 100.
Nortriptyline was also slightly less post a NRI than desipramine.
Unfortunately, I do not have a pubmed account so could not see these numbers in their original content, just the results from the query.
Post-SSRI syndrome: iatrogenic anhedonia, memory and concentration problems, sexual dysfunction. [NOTE no sadness or anxiety]
Location:USA
Currently taking 300mg Olmifon 2.5 fluoxetine(maybe)
poster:conundrum
thread:943541
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/944940.html