Re: Tricyclic most like SNRIs? » bleauberry

Posted by conundrum on February 22, 2010, at 22:23:18 [reposted on February 26, 2010, at 8:36:11 | original URL]

In reply to Re: Tricyclic most like SNRIs?, posted by bleauberry on February 22, 2010, at 19:57:23

Taken from the following study:
http://cat.inist.fr/?aModele=afficheN&cpsidt=2585906
"Duloxetine (5.0 mg/kg, s.c.) and fluoxetine (10.0 mg/kg, s.c.) increased dialysate levels of DA (65 and 60% vs. basal values, respectively), NAD (400 and 90%, respectively), and 5-HT (130 and 110%, respectively) in the frontal cortex (FCX)."
If I'm interpreting this correctly Duloxetine increases norepinephrine more than serotonin or dopamine in the PFC. Perhaps this isn't true through out the brain but it probably has clinical significance.

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Re: Tricyclic most like SNRIs? » bleauberry conundrum 2/26/10
Re: Tricyclic most ..... - Adding Buspar And Rats Brainbeard 2/26/10
Re: Tricyclic most ..... - Adding Buspar And Rats » Brainbeard conundrum 2/26/10
Re: Tricycl.. - Duloxetine's Mysterious NE-raising Brainbeard 2/26/10
Re: Tricyclic most like SNRIs? bleauberry 2/26/10
Re: Tricyclic most like SNRIs? » bleauberry conundrum 2/26/10

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