Re: Tricyclic most like SNRIs? » bleauberry

Posted by conundrum on February 22, 2010, at 22:23:18

In reply to Re: Tricyclic most like SNRIs?, posted by bleauberry on February 22, 2010, at 19:57:23

Taken from the following study:
http://cat.inist.fr/?aModele=afficheN&cpsidt=2585906
"Duloxetine (5.0 mg/kg, s.c.) and fluoxetine (10.0 mg/kg, s.c.) increased dialysate levels of DA (65 and 60% vs. basal values, respectively), NAD (400 and 90%, respectively), and 5-HT (130 and 110%, respectively) in the frontal cortex (FCX)."
If I'm interpreting this correctly Duloxetine increases norepinephrine more than serotonin or dopamine in the PFC. Perhaps this isn't true through out the brain but it probably has clinical significance.

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Tricyclic most like SNRIs? bearfan 2/21/10
Re: Tricyclic most ..... - How About Imipramine? Brainbeard 2/21/10
Re: Tricyclic most ..... - How About Imipramine? » Brainbeard Phillipa 2/21/10
Re: Tricyclic most ..... - How About Imipramine? » Phillipa Bob 2/21/10
Re: Tricyclic most ..... - How About Imipramine? » Bob Phillipa 2/21/10
Re: Tricyclic most like SNRIs? gman22 2/22/10
Re: Tricyclic most like SNRIs? bleauberry 2/22/10
Re: Tricyclic most like SNRIs? » bleauberry conundrum 2/22/10
Re: Tricyclic ..... - Imipramine And Desipramine Brainbeard 2/23/10
Redirect: dialysate levels Dr. Bob 2/26/10

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