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Re: Tricycl.. - Duloxetine's Mysterious NE-raising

Posted by Brainbeard on February 23, 2010, at 17:30:53 [reposted on February 26, 2010, at 8:36:11 | original URL]

In reply to Re: Tricyclic most ..... - Adding Buspar And Rats » Brainbeard, posted by conundrum on February 23, 2010, at 14:04:07

> True but my point was that despite higher ratio for 5HT to NE it still increased NE a lot in the rat PFC. It increased it 400% compared to the 130% in serotonin. I'm sure that varies in other parts in the brain and in humans, but I'm just trying to point out it may have a clinical effect for some.

You're right. Duloxetine might have some other mechanism besides NRI through which it raises NE..

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poster:Brainbeard thread:937959
URL: http://www.dr-bob.org/babble/neuro/20100223/msgs/937962.html