Posted by Brainbeard on October 11, 2009, at 15:10:24
In reply to Re: question for brainbeard., posted by metafunj on October 11, 2009, at 14:44:53
Amitriptyline's SRI is not very strong, but admittedly it is there. The SRI to 5HT2A-antagonism ratio of amitriptyline might be similar to that of Prozac (slightly stronger SRI), but again, I think only a little 5HT2A/C-antagonism can do the trick, while a little SRI is probably hardly noticeable.
Mirtazapine (Remeron) is actually such a strong 5HT2C-blocker that the side-effects of 5HT2C-antagonism - constant food craving, massive weight gain - may outweigh the benefits. It's also a stronger antihistaminergic than amitriptyline - probably it's the strongest antihistaminergic on the planet.
I myself am living proof that you can become tolerant to H1-antagonism, but there could be a limit to such tolerance. Remeron seems to reduce many people's ambitions to sleeping, eating and having sex.
Still, I would like to try it sometime. With amitriptyline, the potential cardiac risk bothers me (I'm a hypochondriac, so there I go).
poster:Brainbeard
thread:919193
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/920507.html