Posted by Brainbeard on October 11, 2009, at 14:22:56
In reply to Re: question for brainbeard., posted by metafunj on October 11, 2009, at 12:22:48
> So far I don't notice anything at 5 Mgs a day except for feeling slightly drowsy in the morning and headaches. Also I tend to be eating less not more.
You should take Buspar with it. Buspar boosts the dopamine up further when combined with Prozac.
Thing is, the effect of low dose Prozac is pretty.. subtle. So if you're expecting anything spectacular, you're bound to be disappointed. For me, the moodlifting effect was quite noticeable, but I also had moments of intense despair while on this combination. One token of 5HT2C-antagonism in my case was that I unexpectedly but rapidly gained weight while on low dose Prozac - and it took pretty long to lose it after I quit.
Right now, I'm taking amitriptyline for 5HT2C-antagonism. Well, amitriptyline actually is a 5HT2C inverse agonist, according to some sources, but who cares, since the effect seems to be the same. Amitriptyline is also a 5HT2A-antagonist. I had outruled it as an option for 5HT2A/C-antagonism because it's such a strong antihistaminergic. But I've discovered that I become tolerant to its sedation rather quickly. I reached 50mg recently and the benefits of 5HT2A/C-antagonism are there for sure. Lifted mood, renewed energy and motivation, and beyond doubt, restored sex drive and sexual function. Not bad for such a golden oldie. Only trouble is the anticholinergic side-effect of brain fog.
Yesterday night, I decided to do a little experiment (n=1) and take 100mg of Zoloft (sertraline) with 50mg of amitriptyline. Theoretically, amitriptyline, by its 5HT2A-antagonism, should counter Zolofts tendency to disrupt sound sleep. I've tried 100mg of Zoloft before and slept very bad on it. This time, with the 50mg of amitriptyline added, I slept like a log. I didn't get the chance to test my sexual functioning on this combination today. Theoretically, the right amount of amitriptyline should also counter SSRI-induced sexual dysfunction.
poster:Brainbeard
thread:919193
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/920502.html