Posted by sowhysosad on September 16, 2009, at 20:07:44
In reply to Re: imipramine ) Inhibition of 5-HT Uptake Pump (%), posted by Brainbeard on September 16, 2009, at 13:06:04
> I can't find the potency data for imipramine anywhere on the page!
Oops! Botched link! Try figures 6.3 and 6.4 here:
http://www.preskorn.com/books/omd_s6.html#fig6-3
> Escitalopram (Lexapro) on the other hand is truly the most selective and potent SSRI.
I can't find any data for escitalopram but do I recall reading it's not the most potent SRI in terms of affinity for the serotonin uptake pump - sertraline or paroxetine would claim that title.
The only sources I can find claiming escitalopram is the most potent SSRI are Lundbeck's own literature, and forums where the claim isn't backed up with any data.
Its selectivity - not affinity - for the 5-HT pump is what makes it unusual amongst SSRI's as far as I'm aware.
I may well be wrong though - does anyone have any data?
> I suspect that claims about less sexual side-effects are the result of marketing hype and myth-building rather than an accurate representation of reality.Again I've no hard evidence but, anecdotally, some people on Babble claim it's caused them the least sexual sides of all the SRI's.
Certainly sexual issues were minimal for me at 10mg, but more troublesome at 20. Still way better than fluoxetine or paroxetine in that respect though.
poster:sowhysosad
thread:909605
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/917393.html