Posted by sowhysosad on September 16, 2009, at 11:54:19
In reply to Re: imipramine ) Inhibition of 5-HT Uptake Pump (%), posted by Brainbeard on September 16, 2009, at 8:42:46
> > According to Preskorn it [imipramine, BB] has less affinity for the serotonin uptake pump than all of the SSRI's but is equal to venlafaxine.
>
> That ain't right. Are you sure Preskorn said that? Got a link?http://www.preskorn.com/books/omd_s6.html
Figures 6.3 and 6.4 on that page.
> Despite your experience, the fact that imipramine causes sexual dysfunction in therapeutical doses illustrates that it has potent SRI action.Good point. I think I had some problems in that area, plus some erectile dysfunction which I believe was caused by hypotension.
> Fluvoxamine causes the least sexual dysfunction of all (S)SRI's, which is not surprising seeing that it is weaker than imipramine.A lot of people claim escitalopram causes the least but - in line with your reasoning - some data show it's a fairly weak (but very selective) SRI.
> The NRI, which is indeed strong with imipramine, might overshadow the SRI (which doesn't mean that it's not there).Yeah, you could well be right.
poster:sowhysosad
thread:909605
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/917356.html