Posted by Brainbeard on August 18, 2009, at 4:31:06
In reply to Re: imipramine ) Inhibition of 5-HT Uptake Pump (%), posted by SLS on August 1, 2009, at 6:18:43
I can't find it right now, but Dr. Ken Gillman had a table suggesting that imipramine was in between citalopram (Celexa, less strong) and fluvoxamine (Luvox, stronger!) as for SRI potency.
I have been wondering myself how much imipramine would be necessary to reach the usual 80% 5HT receptor occupation. I don't know how 5HT receptor affinity relates to drug concentration, but if 50mg of citalopram is enough to reach about 80% 5HT occupancy, and 150mg of fluvoxamine is enough, and imipramine ranks in between, might it be that about 75mg of imipramine might be enough for some serious SRI? Or am I being an irresponsible amateur dumb *ss here?
poster:Brainbeard
thread:909605
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/912760.html