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Re: Dopamine depletion: A myth? Tryciclics + SNRIs

Posted by SLS on May 18, 2009, at 7:24:46

In reply to Re: Dopamine depletion: A myth? Tryciclics + SNRIs, posted by Meltingpot on May 17, 2009, at 10:40:52

> Hi,
>
> So if SSRIs do somehow decrease dopamine activity then can the same be said for tricyclics and SNRIs??
>
> Denise

I believe that this is more of an acute effect of these drugs rather than the result of chronic exposure. My guess is that the long-term effects of 5-HT reuptake inhibitors are to actually reset the balance of neurotransmission dynamics such that dopaminergic activity in certain critical dopaminergic pathways is INCREASED rather than decreased.

I do not believe that the apathy, amotivation, anorgasmia, and decrease libido that occurs during chronic use of a serotonin reuptake inhibitor has anything to do with some sort of global depletion of dopamine.


- Scott

 

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poster:SLS thread:889604
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/896408.html