Posted by metafunj on September 12, 2009, at 11:16:38
In reply to Re: Dopamine depletion: A myth? Tryciclics + SNRIs, posted by Meltingpot on May 17, 2009, at 10:40:52
Denise this study seems to indicate that SSRIs do decrease dopaminergic neurotransmittion. SSRIs decrease Serotonin transporters(SERT) and increase Dopamine transporters(DAT).
Decreased SERT means serotonin can hang around longer in the synapse and increased DAT means that dopamine gets taken out of the synapse faster. The abstract below shows that this occurs.
Abstract
Serotonin and dopamine transporter (SERT, DAT) availabilities have prospectively been investigated using [123I]β-CIT and single photon emission computed tomography in subjects with obsessive–compulsive disorder under treatment with the selective serotonin reuptake inhibitor citalopram. SERT availability decreased by a mean 36.5%, whereas DAT availability increased by about 40%. The data point at a citalopram induced modulation of both serotonergic and dopaminergic activity and support the notion of functional interactions of monoaminergic systems in the human brain.
Keywords: Serotonin and dopamine transporters; Single photon emission computed tomography; β-CIT; Serotonin reuptake inhibitor; Obsessive–compulsive disorder
poster:metafunj
thread:889604
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/916658.html