Posted by myco on March 5, 2009, at 13:35:17
In reply to Re: Do SSRI's cause dopamine depletion, posted by desolationrower on March 4, 2009, at 20:54:14
I think I read something about this...ssri's causing regrowth or neurons and "repair" of damaged ones...leading into a theory of a neuroprotection of sorts and extended remission after med withdrawal.
Question would be do you think this has more to do with the reuptake inhibition characters of the newer meds? Do you think the same idea could be proposed for MAOI's aswell? At this point, I have no qualms about remaining on nardil for the long term.
myco
> i'm not sure we know things return to normal, sris increase serotonergic dendritic branching, and i don't know how much that reverses. generally that is considered part of the positive effect reversing depression. there is not much in the way of long-term research on antidepressants. its expensive enough doing a 6 week trial. this is one reason there is little research done on balding, it takes 6 months for effects to be seen, which makes any trial quite costly.
>
> some 5ht neurons exert an inhibitory effect on DA neurons.
>
> there are 5ht receptor antagonists that have positive effect on DA levels in some situations. The other main avenue is more direct activation of DA neurons, something like bupropion is the most common option.
>
> -d/r
poster:myco
thread:883495
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/883928.html