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Re: Imipramine really that good? » SLS

Posted by med-amorphosis on May 17, 2010, at 15:18:22

In reply to Re: Imipramine really that good? » med-amorphosis, posted by SLS on May 17, 2010, at 14:57:24

> I would say that imipramine demonstrates a greater success rate than desipramine.
>
> When combined with an MAOI, imipramine might have a greater potential to produce serotonin toxicity when compared to lofepramine. I think lofepramine is a prodrug that is converted to desipramine in the body. Desipramine is selective enough for NE that it be safer with an MAOI. I experience a degree of serotonin syndrome when I combine imipramine with Nardil.
>
> How did you come to take 90mg of Marplan? Are you convinced that it helps you more than 60mg? I am in the process of titrating Marplan. However, I doubt that my doctor will go any higher than 60mg.
>
> Thanks.
>
>
> - Scott

Not even MDMA produces serotonin syndrome with my meds. Its quite pleasant. Surprisingly. Anyway.
At 60mg my previous pdoc suggested upping Marplan to 80mg seeing as I had no side effects. I then took myself to 90. Its a far less toxic-feeling drug than Nardil. But then Nardil does so much more.

 

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