Posted by med-amorphosis on May 17, 2010, at 15:11:22
In reply to Re: Imipramine really that good?, posted by ed_uk2010 on May 17, 2010, at 14:50:01
> > My current regime is:
> > 90mg isocarboxazid (Marplan).
> > 210mg lofepramine.
> > 4mg clonazepam (Klonopin).
> > 1.5g L-Tryptophan - now ditched coz of excessive hypersomnia.
>
> Imipramine cannot be combined with MAOIs because it inhibits the reuptake of serotonin. The combination could cause severe toxicity. Lofepramine is different because it is essentially a noradrenergic antidepressant.
>
> If you want to try imipramine you'd need to come of lofepramine and isocarboxazid first. You could start imipramine once you had been completely off isocarboxazid for three weeks.So why has my pdoc included it in the list of TCAs he 'will' consider adding to my MAOI, as well as amitryptyline? I was slightly shocked too, but Hes very experienced. Anyway, imipramine is greatly more potent as an NRI than SRI, esp as its broken down to desipramine anyway. No?
poster:med-amorphosis
thread:947687
URL: http://www.dr-bob.org/babble/20100514/msgs/947694.html