Posted by SLS on April 24, 2009, at 6:18:16
In reply to Re: How much time for the MAO Inhibition?, posted by shasling on April 24, 2009, at 1:03:01
Hi Shasling.
At the moment, I am still of the opinion that it takes far less than 4-8 weeks to reach an equilibrium of MAO inhibition at a given dosage. I will here try to defend my position.
The 4-5 weeks in the article seems to include the time it takes to titrate to the therapeutic dose that produces a clinical improvement. I say this because they didn't indicate otherwise. Furthermore, they used clinical response as their gauge of MAO inhibition such that it was at this point that they decided to assay blood MAO activity. It usually takes a minimum of 2 weeks to see results from the time you reach a therapeutic level (Which could be 3-4 weeks). In consideration of these two factors, I would say that it is not necessary to wait so long to reach 85% platelet MAO inhibition. It took me only two weeks according to the MAO blood test I had taken. Granted, this was over 20 years ago, so I don't know how well that reflects the assay results they reported in the study.
- Scott
poster:SLS
thread:892451
URL: http://www.dr-bob.org/babble/20090416/msgs/892494.html