Posted by SLS on April 25, 2009, at 19:09:22
In reply to Re: How much time for the MAO Inhibition? » SLS, posted by tepi on April 25, 2009, at 18:48:03
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> > Wild guess - 10-14 days at a steady dosage?
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> > Definitely not 4-8 weeks.
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> > After you reach the percentage of inhibition that is right for you, you need to expect to remain there for 3 weeks to see some improvement. This may represent the time necessary for the compensatory changes that occur in receptor binding. There is approximately a 2 week turnover in receptors, so one might suspect changes in receptor numbers to be involved in the antidepressant response, and why that response is latent to the initial drug exposure.
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> > - Scott
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> Scoot do you think that using higher dosages per day can make this time a little shorter?
Yes.Some doctors swear that with some of their patients, they had to go higher in dosage to obtain adequate MAO inhibition, whereupon they were able to reduce the dosage to maintain a treatment response. The only question I have is: What's the rush? I don't know how safe it is for Parnate in particular to use a loading dose strategy. Doing so might precipitate a hypertensive reaction unnecessarily. My recommendation is to remain alive and titrate more gradually.
- Scott
poster:SLS
thread:892451
URL: http://www.dr-bob.org/babble/20090416/msgs/892781.html