Posted by jrbecker on December 23, 2005, at 16:10:23
In reply to Re: Effexor metabolite submitted for FDA approval » jrbecker, posted by ed_uk on December 23, 2005, at 15:36:05
> Hi J
>
> Do you know what the brand name will be?
>unfortunately, I don't.
> >imipramine and desipramine
>
> The think is, desipramine (a major metabolite of imipramine) is pharmacologically quite different to imipramine. Desipramine is a selective NRI with low affinity for other receptors eg. alpha receptors, muscarinic receptors etc. Imipramine has a high affinity for both alpha receptors and muscarinic receptors.
>
> In contrast to this, both venlafaxine and desvenlafaxine are 'simply' serotonin and NE reuptake inhibitors with (presumably) very similar pharmacological effects.
>
> Regards
>
> Edthanks for clarifying.
JB
poster:jrbecker
thread:591573
URL: http://www.dr-bob.org/babble/20051221/msgs/591628.html