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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by english on September 30, 2009, at 22:43:12
I see that selegiline is listed as contradicted in the strattera monograph. EMSAM is also listed (emsam being nonselectively an MAO-A/B inhibitor, selegiline only inhibiting MAO-B within normal dose ranges).
as they both work on different neurotransmitter systems (although a related one since DA > NE?) i wouldn't intuitively assume the two would cause problems together.
could it be dangerous? if it wouldn't be while selegiline still retains it's selective MAO-B inhibition, i'd still be concerned dosing with the liquid citrate as the sublinqual administration has been shown to raise bodily concentration of selegiline 5 fold over oral metabolism. apparently 5mg sublingual selegiline = 25 mg of oral selegiline HCL (i have an abstract if anyone is interested), potentially entering nonselective territory. nonetheless, i've never heard of anyone encountering a hypertensive reaction at such a dosage of the liquid. thoughts?
Posted by Brainbeard on October 3, 2009, at 15:58:22
In reply to Atomoxetine and Selegiline - contradicted?, posted by english on September 30, 2009, at 22:43:12
I wouldn't know about the liquid - if it really increases bio-availability five-fold, you should either take a lower dose or switch to oral ingestion, I guess. Above 10mg, selegiline begins losing selectivity, and around 50mg and above, you can really kiss your selectivity goodbye.
What could be a problem is that both atomoxetine and selegiline tend to raise blood pressure and increase pulse. So if you take them together, it might be wise to monitor these. Got a blood pressure meter? They're cheap nowadays, and it's lots of fun to keep track of your BP and pulse.
'Look, Mum, my scores are getting higher and higher!!'
Posted by Rosy Crucifiction on October 25, 2009, at 19:01:12
In reply to Atomoxetine and Selegiline - contradicted?, posted by english on September 30, 2009, at 22:43:12
I wouldn't do it. Strattera boosts norepinephrine. Even small amounts of excess norepinephrine can cause a blood pressure spike. You could stroke out. I've tried tiny doses of selegiline with wellbutrin and regretted it. If you ever do try something like this, make sure you have a strong antihypertensive on hand and a phone that works.
Posted by Rosy Crucifiction on October 25, 2009, at 19:10:37
In reply to Re: Atomoxetine and Selegiline -contradicted? YES!, posted by Rosy Crucifiction on October 25, 2009, at 19:01:12
This is a good site to check interactions for FDA approved drugs. They're thorough and Elsevier is to be trusted.
http://cpref.goldstandard.com/inter.asp?r=8084
This site you can check non-FDA drugs. You should register first. It's free:
http://www.mims.com
I'd like to know if anyone has a good European site.
Posted by mtdewcmu on December 2, 2009, at 14:39:07
In reply to Atomoxetine and Selegiline - contradicted?, posted by english on September 30, 2009, at 22:43:12
Mixing the two can cause seizures and severe hypertension. Although, my source hints that it might be safe with low enough doses of selegiline (less than 30mg/day).
This is the end of the thread.
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