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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 6 of 6. This is the beginning of the thread.
Posted by myco on March 30, 2009, at 22:21:36
Recently came across an article that suggests that prolonged use of MAOIS (study uses clorgyline, deprenyl and phenelzine) will decrease the firing rate of dopamine systems using rats as models. Short term use of MAOI's had no effect on inhibition/decrease of DA firing rates. They were able to "restore" DA to it's normal firing rate under the use of clorgyline with the short term addition of para-chlorophenylalanine.
Any comments on this? Anyone used para-chlorophenylalanine or some other compound to increase DA effect while on a MAOI long term?
Reference:
----------Chenu et al. 2008. Long-term administration of monoamine oxidase inhibitors alters the firing rate and pattern of dopamine neurons in the ventral tegmental area. Int J Neuropsychopharmacol. Aug 13: pp 1-11.
Posted by myco on March 30, 2009, at 22:30:42
In reply to Long term MAOI use slows DA system firing rates, posted by myco on March 30, 2009, at 22:21:36
Is it as simple as inhibiting seratonin synthesis with a compound like this?
Posted by desolationrower on March 31, 2009, at 1:50:11
In reply to Re: Long term MAOI use slows DA system firing rates » myco, posted by myco on March 30, 2009, at 22:30:42
instead of killing off your 5ht neurones, you could just block 5ht3 :)
oh, and i was looking for the cite for this (saw it a while ago when deciding on adding memantine to my maoi), and wondering why i couldn't find it, until i realized it was the same abstract as you posted. look at the part you didn't post.
-d/r
Posted by myco on March 31, 2009, at 2:14:08
In reply to Re: Long term MAOI use slows DA system firing rates, posted by desolationrower on March 31, 2009, at 1:50:11
d/r,
Not to sound dense here (it's after 1am and i'm tired)...um:
"Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?
Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
myco
---------------------------------
> instead of killing off your 5ht neurones, you could just block 5ht3 :)
>
> oh, and i was looking for the cite for this (saw it a while ago when deciding on adding memantine to my maoi), and wondering why i couldn't find it, until i realized it was the same abstract as you posted. look at the part you didn't post.
>
> -d/r
Posted by desolationrower on March 31, 2009, at 4:19:49
In reply to Re: Long term MAOI use slows DA system firing rates » desolationrower, posted by myco on March 31, 2009, at 2:14:08
> d/r,
>
> Not to sound dense here (it's after 1am and i'm tired)...um:
>
> "Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
>
> Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?htats what i think that paper says.
> Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
not much, maybe a bit more solid antidepressant effect (i'm pretty med insensitive tho)
-d/r
Posted by myco on March 31, 2009, at 11:53:08
In reply to Re: Long term MAOI use slows DA system firing rates, posted by desolationrower on March 31, 2009, at 4:19:49
lol now i'm overly interested. Nardil is slowing in efficacy in terms of energy and concentration...still excellent for anxiety although breakthroughs do happen. I had always thought that the DA/NA effect was the issue with this now it seems it's a likely possibility and 'treatable' without stimulants...hmm wonder if I can "gp word" this correctly as to not put him off.
> > d/r,
> >
> > Not to sound dense here (it's after 1am and i'm tired)...um:
> >
> > "Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
> >
> > Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?
>
> htats what i think that paper says.
>
> > Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
>
> not much, maybe a bit more solid antidepressant effect (i'm pretty med insensitive tho)
>
> -d/r
This is the end of the thread.
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