Posted by myco on March 31, 2009, at 2:14:08
In reply to Re: Long term MAOI use slows DA system firing rates, posted by desolationrower on March 31, 2009, at 1:50:11
d/r,
Not to sound dense here (it's after 1am and i'm tired)...um:
"Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?
Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
myco
---------------------------------
> instead of killing off your 5ht neurones, you could just block 5ht3 :)
>
> oh, and i was looking for the cite for this (saw it a while ago when deciding on adding memantine to my maoi), and wondering why i couldn't find it, until i realized it was the same abstract as you posted. look at the part you didn't post.
>
> -d/r
poster:myco
thread:887823
URL: http://www.dr-bob.org/babble/20090330/msgs/887846.html