Posted by desolationrower on March 31, 2009, at 4:19:49
In reply to Re: Long term MAOI use slows DA system firing rates » desolationrower, posted by myco on March 31, 2009, at 2:14:08
> d/r,
>
> Not to sound dense here (it's after 1am and i'm tired)...um:
>
> "Since ondansetron completely reversed the effects of clorgyline on DA neuronal activity, the effects of MAOA inhibition appeared to be mediated by 5-HT3 receptors."
>
> Youre saying that adding memantine or ondansetron or another compound that antagonizes 5-ht3 (blocks 5ht3) will reverse some of the DA attenuation caused by prolonged use of a MAOI?htats what i think that paper says.
> Also...Can you tell me what memantine does for you...like does it bring back a lost effect you had on parnate?
not much, maybe a bit more solid antidepressant effect (i'm pretty med insensitive tho)
-d/r
poster:desolationrower
thread:887823
URL: http://www.dr-bob.org/babble/20090330/msgs/887851.html