Posted by metafunj on September 12, 2009, at 2:03:05
In reply to Re: The Final Pathway To The Dopaminergic Pot Of G, posted by ABMIND on July 6, 2009, at 7:46:07
I have suffered with anhedonia as well as concentration memory problems ever since stopping prozac about 6 years ago. I was stubborn and thought my brain would heal if I left it alone, but it has only gotten worse with time.
I was told by a neurologist friend that SSRIs can leave someone with excess serotonin because they no longer have as many 5HT transporters after years of SSRI use.
If this is the case, then I continue to have elevated serotonin but no longer have the 5 HT2C antagonism I had while on prozac. Now the the elevated serotonin could be agonizing the 5 HT2C
receptor decreasing dopamine and norepinephrine release.I'm thinking of trying it again at a low dose for 5 HT2C blockade. Other possible candiates are Remeron for 2A/2C blockade or the anti histamine Cyproheptadine, which also has 2A/2C blockade and is used for the treatment of serotonin syndrome.
I was also considering trying Buspar to lower my overall serotonin levels through its 5HT1A agonism. I believe Ginkgo biloba also decreases serotonin release.
Maybe a combination of the low dose prozac and buspar could lead to that pot of gold.
If its a problem of serotonin acting against dopamine I'd rather fix that problem than just take stimulants, or something like provigil.
I hope everyone here is finding something that works.
poster:metafunj
thread:904542
URL: http://www.dr-bob.org/babble/neuro/20090701/msgs/916605.html