Posted by morganpmiller on July 1, 2009, at 2:28:58
In reply to Re: Can serotonin reuptake inhibition be countered?, posted by Brainbeard on June 30, 2009, at 9:54:54
It's so weird how I keep hearing about these things that Zoloft can do to you. I was on it for 8 years and always felt strong like and ox, super energized, very motivated, and never once had an issue with sexual side effects. I know many others that have felt the way I did on Zoloft. I believe that some people can experience the negative side effects discussed hear. I just think it is funny that these side effects are talked about in a way that most that take a drug like Zoloft are doomed to suffer them.
Like I mentioned before, I seriously doubt that it takes up to 300 mgs of Zoloft to get a significant boost in dopamine. I can't prove this, but there are plenty of people out there that can testify to feeling dopamine-like effects when taking Zoloft at 100mgs or more.
> I understand its complicated, beyond what I understand, but zoloft really does, imo, have an adverse effect on dopamine for me.
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> Of course Zoloft has adverse effects on dopamine: it's a strong SSRI, and any strong SRI has strong anti-dopaminergic effects, manifesting in loss of libido most prominently and possibly lethargy and apathy. Any strong SRI will raise prolactin levels, which is a sign of anti-dopaminergic action. Zoloft can raise prolactin levels wildly.
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> The dosage question is key, since the anti-dopaminergic effects of Zoloft are bound to be dose-related. That's why I'm hoping to avoid them myself with a low dose of Zoloft. Low definitely means <50mg, since at 50mg sertraline (Zoloft) already occupies 80% of serotonin transporters, which comes down to full SRI in a therapeutic sense.
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> Current meds: imipramine 12.5mg + amitriptyline 6mg at bedtime; sertraline 12.5mg + ondansetron 2mg + modafinil 50mg in the morning
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> 'Some of the Magic Syrup was Preserved'
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poster:morganpmiller
thread:901465
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/904152.html