Posted by Brainbeard on June 30, 2009, at 9:54:54
In reply to Re: Can serotonin reuptake inhibition be countered?, posted by garnet71 on June 29, 2009, at 22:31:26
> I understand its complicated, beyond what I understand, but zoloft really does, imo, have an adverse effect on dopamine for me.
Of course Zoloft has adverse effects on dopamine: it's a strong SSRI, and any strong SRI has strong anti-dopaminergic effects, manifesting in loss of libido most prominently and possibly lethargy and apathy. Any strong SRI will raise prolactin levels, which is a sign of anti-dopaminergic action. Zoloft can raise prolactin levels wildly.
The dosage question is key, since the anti-dopaminergic effects of Zoloft are bound to be dose-related. That's why I'm hoping to avoid them myself with a low dose of Zoloft. Low definitely means <50mg, since at 50mg sertraline (Zoloft) already occupies 80% of serotonin transporters, which comes down to full SRI in a therapeutic sense.
--------------------------------------------------------------------------------------------------------------
Current meds: imipramine 12.5mg + amitriptyline 6mg at bedtime; sertraline 12.5mg + ondansetron 2mg + modafinil 50mg in the morning'Some of the Magic Syrup was Preserved'
--------------------------------------------------------------------------------------------------------------
poster:Brainbeard
thread:901465
URL: http://www.dr-bob.org/babble/neuro/20090129/msgs/903966.html