Posted by ed_uk2010 on August 4, 2010, at 16:49:52
In reply to Re: All my drugs work for 2-7 days then stop working, posted by tiopenster on August 4, 2010, at 16:28:52
>How can it be a weak inhibitor of serotonin and yet have a strong antagonism for 5ht2. Isn't that a contradiction? Is inhibition different from antagonism?
It's just saying that it's got weak activity at 5-HT(1) receptors, but strong antagonism at 5-HT(2) receptors. Antagonism means that a receptor is 'blocked' - preventing it from being stimulated.
>Would you recommend switching out Remeron & Geodon for Surmontil or merely adding it?
It was only a suggestion. First of all, you would need to discuss it with your doctor. He may not think that it is suitable.
If you do decide to try it, I do think that you should stop Neurontin first. You can't just keep on adding meds! Surmontil should be started at a low dose and increased gradually, anticholinergic side effects such as dry mouth can be bothersome. After starting Surmontil, I would suggest reducing Geodon first then Remeron later. Once you have increased up to a therapeutic dose of Surmontil, you may be able to stop both Remeron and Geodon.
I can't promise that Surmontil will be a good med for you. It does cause side effects very frequently eg. drowsiness, dry mouth, constipation, dizziness etc. I was just thinking that its serotonin receptor blocking effects might be useful, and that it's a bit different to anything you've tried before.
poster:ed_uk2010
thread:956187
URL: http://www.dr-bob.org/babble/20100731/msgs/957213.html