Posted by tiopenster on August 4, 2010, at 16:28:52
In reply to Re: All my drugs work for 2-7 days then stop working, posted by ed_uk2010 on August 4, 2010, at 16:02:26
Yes, I think most of the benefit comes from Remeron although it does make me unstable. I have gone off Lyrica and didn't do so well, so it has to be helping some. I've also gone off Geodon alone and I struggled a bit. It seems there is some synergy in what I'm using now, but it's not getting me where I need to be. I should probably try to get off Neurontin and see what happens. I have tried Remeron by itself, but it seems to require some of these other drugs to get it's most effect.
I had read about some of those Zocor side effects. That's why I went off (in addition to the liver problem) I was on Zocor from Sept 27, 2009 until about 3 weeks ago.
I've never heard of trimipramine (Surmontil) let alone use it. The only TCA I've used is Pamelor, but it gave me the 2 good days, then bad again problem. Below is a quote from wikipedia in reference to Surmontil. How can it be a weak inhibitor of serotonin and yet have a strong antagonism for 5ht2. Isn't that a contradiction? Is inhibition different from antagonism?
"Trimipramine's mechanism of action differs from other TCAs. It is only a moderate reuptake inhibitor of norepinephrine, and a weak reuptake inhibitor of serotonin and dopamine. Its main effects are due to considerable receptor antagonism as follows:
Strong: 5-HT2, mACh, H1, H2, α1-adrenergic
Moderate: D2
Weak: 5-HT1, a2-adrenergic"Would you recommend switching out Remeron & Geodon for Surmontil or merely adding it?
poster:tiopenster
thread:956187
URL: http://www.dr-bob.org/babble/20100731/msgs/957209.html