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Anti-Cortisol Therapy: metyrapone and ketoconazole

Posted by SLS on June 29, 2005, at 6:28:35

In reply to Anti-Cortisol Therapy: Remeron ... or Zyprexa?? » Elroy, posted by cache-monkey on June 29, 2005, at 0:34:17

For those people living in the UK, there is an antiglucocorticoid named metyrapone that is used to treat Cushings Syndrome and other hypercortisolemic conditions. I believe metyrapone is also available in Canada. I hope someone can check on this.

Unfortunately, in the US, metyrapone is used only as a test for diagnostic purposes. It helps to differentiate the status of the adrenal glands versus the status of the HPA axis.

Ketoconazole is a cortisol synthesis inhibitor that might be of use for some people.


- Scott

 

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