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Anti-Cortisol Therapy: Remeron ... or Zyprexa?? » Elroy

Posted by cache-monkey on June 29, 2005, at 0:34:17

In reply to Re: HPA Axis and Anti-Cortisol Therapy » Chairman_MAO, posted by Elroy on June 22, 2005, at 20:10:28

Hi Elroy,

I've been reading your posts on cortisol with great interest. Thanks for posting all the useful information.

In some of the links you posted on Remeron as effective cortisol therapy, the authors attribute this to its 5-HT2 blockade. Remeron is known for its 5-HT2a antagonism, but less well known is that it also blocks the 5-HT2c receptors almost as hard [1]. This is a lot like Zyprexa at low doses, although with Z you also get the D-2 antagonsim. So, Zyprexa might present a reasonable altertnative in reducing cortisol levels for people who can't get over the anti-histaminic effects of Remeron.

I only have personal experience with Zyprexa. So far, it seems to have mitigated a fair chunk of my free-floating anxiety that was the residual from a prolonged period of stress.

Just a thought,
cache-monkey

[1] http://www.preskorn.com/columns/0003.html


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