Posted by Ritch on October 27, 2002, at 11:03:52
In reply to Prozac euphoria, posted by turalizz on October 25, 2002, at 14:21:32
> Two years ago, while I was on 60mg/day of prozac; one night I drank alcohol just after taking my third pill of the day, on empty stomach.
>
> I was OK for one or two hours, but when I came home and laid down to sleep, I began to laugh out loud by myself, had a warm euphoric sensation in my body and a massive abdominal twitching sensation. (I had those twitches all the time while I was on Prozac, only not that strong)
>
> Had anyone experienced something like that?
>
> Also, today I read that only 1mg of fluoxetine was enough to totally inhibit the 5-HT reuptake. Since 20 fold of this dose is required to get a response, the antidepressant effect of fluoxetine seems to be related to some other mechanism than 5-HT reuptake inhibition. (the author's opinion, not mine)
> Do we know anything new about the fluoxetine pharmacology?
>
> many thanks,
>
> cemHi, that's an interesting tidbit of information. I wonder if the 1mg number had something to do with a "threshold" level required for the 5-HT transporter to be affected at all instead? It would explain how people can use very small doses of SSRI's for anxiety/mild depression. When I was on Prozac, 2.5mg was the magic number for me (most of the time). That would also explain the "flat" dose-response curve of SSRI's (twice as much tends not to make twice as much difference, etc.).
poster:Ritch
thread:125195
URL: http://www.dr-bob.org/babble/20021025/msgs/125427.html