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Re: Cushings » NikkiT2

Posted by katekite on July 6, 2002, at 9:59:42

In reply to Cushings, posted by NikkiT2 on July 5, 2002, at 16:27:15

That's good you are getting tested.

Growing evidence shows Cushing's often starts in a cyclical or intermittent way, meaning the urine free cortisol test can be normal and someone can still have it. Also people with confirmed Cushing's can still go into the normal range on 10% of their tests.

I read a case report of a teenager who suddenly had the onset of Cushing's symptoms, but always tested normal. She got so bad as to break bones from osteoporosis. She never tested abnormal but ketoconazole made her feel much better. She must have become over-sensitive to cortisol somehow, so that a little was still too much.

I'm not trying to scare or anything here.... Just if you happen to test normal, don't be totally convinced that you have to look elsewhere for answers, since you say you have lots of classic symptoms. The thing to do if you happen to come back normal would be to see an endocrinologist so that you have an expert following you, and consider retesting or doing salivary testing if the endocrinologist thinks its warranted.

Let me know what happens! -- kate


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