Posted by OldSchool on January 21, 2002, at 9:31:42
In reply to Re: What do you all think of Zyprexa for BP?, posted by Blue Cheer 1 on January 20, 2002, at 23:53:34
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> Olanzapine (Zyprexa) has been used to treat all phases of bipolar disorder for several years now.I have the PDR right in front of me and Zyprexa is only FDA approved for the acute management of mania. Im sure some Pdocs are using it off label for longterm management of bipolar disorder, which I personally do not agree with unless real psychosis is present all the time.
>Try a Medline search using keywords "olanzapine bipolar" or "olanzapine fluoxetine". Lilly has been conducting studies using the combination of Zyprexa and Prozac (OFC) for treatment-resistant depression for at least five years (multi-site).
Yeah, I already know that. In fact, I turned down a chance to get into this very study myself which combined Prozac/Zyprexa for TRD. I do not agree with using Zyprexa/Prozac for the management of non psychotic TRD. A person whose problem is unipolar major depression is more susceptible to neuroleptic induced movement disorders than are schizophrenics. Im personally trying to get over EPS induced from low dose Seroquel as I write this and I dont appreciate the Seroquel induced EPS. Zyprexa could have caused the same thing to me.
> All of the atypical APs are used to treat bipolar disorder (psychiatric AIDS). :) Personally, I would exhaust AEDs and/or other drugs before adding a neuroleptic.
I think atypicals should be reserved for REAL psychosis and mania and not for TRD.
Old School
poster:OldSchool
thread:90705
URL: http://www.dr-bob.org/babble/20020116/msgs/90961.html