Posted by Blue Cheer 1 on January 20, 2002, at 23:53:34
In reply to Re: What do you all think of Zyprexa for BP?, posted by OldSchool on January 20, 2002, at 20:50:47
> > I found some good archives on this, but was curious if there were any new opinions? I'm thinking of Zyprexa + Prozac for BPII. (My pdoc has suggested the addition of Zyprexa again.)
> >
> > Zyprexa was actually the first med I tried, 2-1/2 years ago. My eye started to twitch and it didn't seem to do anything, but then I stopped after a few days. My research suggests it works well with Prozac for BP.
> >
> > Any comments appreciated.
> >
> > - KK
>
> I understood that for longterm management of bipolar, mood stabilizers like lithium or depakote were the mainstays. Antipsychotics should be reserved more for the manic episodes, especially when its psychotic mania as is quite common with classic manic depression. Zyprexa is formally FDA approved for short term, ACUTE manic episodes associated with bipolar disorder. I have not read anything about Zyprexa being FDA approved for the more longterm "core" management of bipolar disorder.
>
> If it was me Id be trying to play it safe and stick to the mood stabilisers more. Reserving atypical anti-psychotics for acute mania.
>
> Old School
Olanzapine (Zyprexa) has been used to treat all phases of bipolar disorder for several years now. Try a Medline search using keywords "olanzapine bipolar" or "olanzapine fluoxetine". Lilly has been conducting studies using the combination of Zyprexa and Prozac (OFC) for treatment-resistant depression for at least five years (multi-site). All of the atypical APs are used to treat bipolar disorder (psychiatric AIDS). :) Personally, I would exhaust AEDs and/or other drugs before adding a neuroleptic.Blue
poster:Blue Cheer 1
thread:90705
URL: http://www.dr-bob.org/babble/20020116/msgs/90935.html