Posted by AndrewB on January 3, 2001, at 3:05:41
In reply to Re: Scott- Lamotrigine's AD/dopaminergic action, posted by SLS on January 2, 2001, at 10:34:27
Scott,
I am very busy this week, I will try to answer your questions as soon as possible. Glutaminergic dysfunction is inplicated in physical ailments (i.e gluacoma, hearing loss, neuropathic pain), neurologal deterioration (neuron die off due to excess calcium influx), depression, seizure and cycling activity, cognitive impairiment, schizpophrenia and the list goes on.
Perhaps it is relevant that the glutaminergic system is the largest nuerotramitter system in the brain. Moreover, it has significant pathways into and between the hippocampus, medial prefrontal cortex and the shell of the nucleus accumbens. These are areas of the brain amoung the most responsive and vulnerable (to damage from) stress. For example it was recently shown that excitoxic lesions in the hippocampus impair the emotional conditioning and led to additional glutamate release in the n. accumbens.
Anyway, some drugs are out there to halt in some aspects the damage of various types of glutaminergic dysfunction and restore normal function. Many more are in the investigational stage. I plan to try to learn further what meds are curently available for the beneficial manipulation of parts of the glutaminergic system in order to deal with certain health disorders.
Best wishes,
AndrewB
poster:AndrewB
thread:50592
URL: http://www.dr-bob.org/babble/20001231/msgs/50810.html