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Re: Scott- Lamotrigine's AD/dopaminergic action

Posted by Noa on January 2, 2001, at 11:18:11

In reply to Re: Scott- Lamotrigine's AD/dopaminergic action, posted by SLS on January 2, 2001, at 10:34:27

SLS, you are right--the term Bipolar III is being used to describe depressions with AD-induced hypomania. I just read this in the following abstract:

http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11121824&dopt=Abstract

I could swear I remember reading a previous abstract of work by Akiskal in which he uses BPIII to refer to recurrent depression. Oh well.

I also thought I would mention, as I was reminded when perusing the abstracts, that one of the reasons why these researchers believe there is a diagnostic relationship between recurrent depression and bipolar is that for many people, recurrent depression takes the so called "atypical" form--with "reverse vegetative signs", like hypERsomnia, INcreased appetite, and also have some mood reactivity, whereas "typical" (to me "typical" vs. "atypical" are misnomers) depression, usually non-recurrent, is more often associated with vegetative signs like DEcreased appetite, INsomnia, etc. and very little reactivity (ie, can your depression loosen a bit to allow you to laugh at a joke, etc.).

So, it might also help to ask if your depression falls into either of these types.

And, I also want to say that sometimes mood stabilizers do have AD effect, on their own, or in combo with ADs, regardless of diagnosis.

Regardless of Diagnosis is a point I keep repeating, because I agree with SLS about focusing on the specific experience and treating symptoms or clusters of symtoms and not worrying too much about diagnosis. Every few years, the dx categories change a bit anyway.


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