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Dr. Bob is Robert Hsiung, MD,
[email protected]Shown: posts 1 to 5 of 5. This is the beginning of the thread.
Posted by Katgirl on April 26, 2010, at 19:37:41
You all were such a wonderful font of knowledge when I asked about LU AA21004 (a 5-HT3 antagonist and 5-HT1A partial agonist), that I was wondering if any of you would be able to give me some "technical" information on Agomelatine.
Agomelatine (5-HT2C antagonist, 5-HT2B antagonist, melatonin M1/M2 receptor agonist). I know what the melatonin receptor agonists do, but what about the serotonin receptors?
Any insights into how this drug would work and/or be different than LU AA21004 (besides the sleep stuff with the melatonin--even I can figure that part out! :) would be appreciated.
Also, if anybody in the EU has taken this and has anything to report, that would be great!
Wonder which of these drugs will hit the light of day in the U.S. first!?
Thanks, Katgirl
Posted by desolationrower on April 27, 2010, at 2:35:36
In reply to Valdoxan/Agomelatine, receptor information, posted by Katgirl on April 26, 2010, at 19:37:41
well there are a number of studies out on it, as its been approved in the EU (or at least some parts i think)
http://scholar.google.com/scholar?q=agomelatine&hl=en&btnG=Search&as_sdt=100000000001&as_sdtp=onmostly it looks like a good sleep drug, that won't cause daytime drowsyness.. quite clean, so low side effects but not as effective as kitchen sink drugs.
-d/r
Posted by Katgirl on April 27, 2010, at 10:17:34
In reply to Re: Valdoxan/Agomelatine, receptor information, posted by desolationrower on April 27, 2010, at 2:35:36
Thanks for all the studies.
But what are the individual serotonin sites that are being targeted?
Last time I posted I got tons of information, but I posted on the main site. Maybe thats what I need to do.
Posted by conundrum on April 27, 2010, at 11:34:08
In reply to Re: Valdoxan/Agomelatine, receptor information, posted by Katgirl on April 27, 2010, at 10:17:34
Neurotransmitters doesn't get much traffic. I don't really know what the 5 HT2B receptor does, but blocking the 5 HT2C increases Norepinephrine and dopamine release in some parts of the brain. I know on of those areas is the Prefrontal Cortex, which is involved with mood.
Posted by desolationrower on May 7, 2010, at 19:28:01
In reply to Re: Valdoxan/Agomelatine, receptor information, posted by conundrum on April 27, 2010, at 11:34:08
what i remeber is 2c antagonists increase dopamine release, maybe in the midbrain, and increase slow wave sleep to a greater extent than 2a antagonists
-d/r
This is the end of the thread.
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Dr. Bob is Robert Hsiung, MD,
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