Valdoxan/Agomelatine, receptor information

Posted by Katgirl on April 26, 2010, at 19:37:41

You all were such a wonderful font of knowledge when I asked about LU AA21004 (a 5-HT3 antagonist and 5-HT1A partial agonist), that I was wondering if any of you would be able to give me some "technical" information on Agomelatine.
Agomelatine (5-HT2C antagonist, 5-HT2B antagonist, melatonin M1/M2 receptor agonist). I know what the melatonin receptor agonists do, but what about the serotonin receptors?
Any insights into how this drug would work and/or be different than LU AA21004 (besides the sleep stuff with the melatonin--even I can figure that part out! :) would be appreciated.
Also, if anybody in the EU has taken this and has anything to report, that would be great!
Wonder which of these drugs will hit the light of day in the U.S. first!?
Thanks, Katgirl

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Valdoxan/Agomelatine, receptor information Katgirl 4/26/10
Re: Valdoxan/Agomelatine, receptor information desolationrower 4/27/10
Re: Valdoxan/Agomelatine, receptor information Katgirl 4/27/10
Re: Valdoxan/Agomelatine, receptor information conundrum 4/27/10
Re: Valdoxan/Agomelatine, receptor information desolationrower 5/7/10

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